Viagra wiki:

How does Viagra work? What does Viagra do to the body?


What Does Viagra do?

The earliest known instance of ED medication is mentioned in the Kamasutra. It suggests a mixture of sparrows’ eggs boiled in milk, clarified butter, and honey, which is supposed to work as a sex stimulant for men. Science has come a long way from sparrows’ eggs ever since an oral medication by the name of ‘Viagra’ was developed at Pfizer Laboratories accidentally in 1989.

What is Viagra?

Viagra is one of the popular trade names of sildenafil citrate (C22H30N6O4S). It is a prescription medication used in treating erectile dysfunction and pulmonary arterial hypertension.

Viagra was discovered by accident in Pfizer laboratories by Andrew Bell, David Brown and Nicholas Terrett who were working with sildenafil to explore its potential in treating multiple cardiovascular diseases. Sildenafil, as a drug, has the ability to lower blood pressure. However, test subjects who had volunteered to take the drug for R&D purposes, later literally refused to give it back because the side-effects enabled them to have better erections. After meticulous research, the drug was patented and then allowed for use by Food and Drug Administration on March 24, 1998.

How does Viagra work?

So, what does Viagra do and how does it work? In order to answer these questions, let’s try to get a better understanding of how human penis functions and how erection occurs.

The physiological mechanism of an erection involves the internal secretion of nitric oxide (NO) into the body. NO initiates the enzyme guanylate cyclase. This correspondingly increases secretion of cyclic guanosine monophosphate (cGMP). cGMP induces muscular relaxation thereby dilating or expanding the blood vessels to allow increased blood flow.

Viagra or Sildenafil citrate stimulates the catalytic effect of NO by inhibiting phosphodiesterase type 5 (PDE5); PDE5 is responsible for the degeneration of cGMP in the penis. Thus, by creating more cGMP, more blood can flow into the penis and remain there for longer periods of time thereby aiding and extending erections.

What does Viagra do to the body?

Viagra stimulates and enhances erections. It can thus be used as a remedy for erectile dysfunction (ED) in men. Viagra will only work when there is sexual stimulation involved. Without sexual stimulation, it is useless due to the fact that it is only a secondary inducer.

The effects of Viagra vary among individuals based on multiple factors. Average time to the onset of effect of Viagra in individuals with ED ranges between 20 and 45 minutes.

Brand-name Viagra is available in the form of 25 mg, 50 mg and 100 mg diamond-shaped blue colored tablets. Studies on test subjects suffering from ED with an age range of 18 to 87 provided exemplary results. Each tablet provided positive results in 63%, 74% and 82% of the cases respectively on an increasing dosage scale characterized by improved erections.

Dosage

The patient can take no more than a single pill maximum within a 24-hour timeframe which is to be ingested 30 minutes to 1 hour before sexual intercourse. The usual starting dose is 50mg, which can, nevertheless, be increased or decreased depending on the patient’s medical history.

Side effects of Viagra

So, what does Viagra do and are all of its effects positive? Even though this medication is considered to be one of the best means of treating erectile dysfunction, some of its effects can be very unpleasant, putting it mildly. Fortunately, the latter effects are experienced only by a tiny fraction of the patients.

Serious side-effects
- Bladder pain
- Priapism
- Burning sensation in chest or stomach
- Itching and numbness
- Cloudy urine, increased urination with pain
- Upset stomach
- Abnormal vision
- Bone pain
- Hearing loss
- Scaling or peeling of skin
- Excessive hunger
- Faintness
- Severe headaches
- Nausea
- Nasal congestion

An occurrence of one or more of these side-effects to any individual requires medical supervision – and more serious side effects from the list above such as priapism, vision and hearing abnormalities, chest pain, once experienced, require immediate medical attention.

BV Treatment Over The Counter

Bacterial vaginosis, also called BV or nonspecific vaginitis, is a common infection of the female lower genital tract. In women of reproductive age, BV is the commonest cause of vaginal discharge. Other vaginal diseases that cause a discharge include candidiasis, trichomoniasis, and cervicitis.

Bacterial vaginosis is usually observed when there is an imbalance of the bacterial populations that are normally found in the vagina. The imbalance can be triggered by douching, taking antibiotics, and the use of an intrauterine device. The vaginal microflora is usually acidic with this acidity being maintained by a group of bacteria called lactobacilli. When the numbers of the lactobacilli are reduced, the harmful bacteria increase in numbers, which may result in an outbreak of vaginosis. Some of the bacteria that are found in BV samples are Gardnerella vaginalis, Mobiluncus spp., Bacteroides spp., and Mycoplasma hominis. Earlier on, the condition was thought to be caused solely by Gardnerella, and it was thus called Gardnerella vaginitis, but this point of view has been proven wrong.

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How to Treat BV Over the Counter

What is Bacterial Vaginosis? Bacterial Vaginosis, also referred to as vaginitis or non-specific vaginitis, is a mild infection that is brought about by an imbalance of certain types of bacteria in the vagina. Typically, the vagina has ‘good’ (healthy) and ‘bad’ bacteria; the former being the ones that keep the latter in check. Should the balance of good bacteria and bad bacteria be upset, for one reason or another, leaving the bad bacteria to thrive, BV develops. It is normally characterized by a vaginal discharge with foul odor.

Until recently most healthcare specialists would agree that bacterial vaginosis was caused by Gardnerella Vaginalis – an anaerobic species of bacteria capable of disrupting normal human microflora. Recent research, however, has showed that there are other species of bacteria, besides Gardnerella, that cause BV. This condition is regarded as the most common infection of the vagina affecting women aged between 15 and 45.

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Cialis Online

What Is Cialis? Sooner or later there comes such a sad situation in the life of any man, when because of some reason he can’t achieve an erection. This may be connected with a plenty of negative factors in the life of a man, physiological ones as well as psychological. What is modern life? Stresses day and night, bad habits, unhealthy food, sedentary lifestyle, use of alcohol, contaminated air – nothing from this list adds power to male health. As a result, a lot of age-related changes are perceived by us as natural, but are not natural at all and appear because of the lack of care about our health. Sexual health of a man is extremely vulnerable, unlike a lot of people think, and it is not surprising that any drug developed for the treatment of erectile dysfunction that enters the pharmaceutical market immediately draws attention to itself.

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Cialis Dosage

What A Drug Is Cialis? Cialis is a well-known drug used for the treatment of erectile dysfunction. It is not so popular as Viagra, because Viagra was invented earlier and got itself all the glory of the best drug against ED in men. However, such a situation is far from justice, because the effect of Cialis is even better, and the drug has got considerably less contraindications and side effects. Thus, it is much safer in use.

Nowadays, more than one hundred millions of men all around the world suffer from erectile dysfunction – and these are only those men who reported about their intimate problem to the doctors. The number of those who consider it impossible to consult with anyone about their intimate health is immeasurably more. In general, according to the estimates of the scientists, almost every third man in the age between 35 and 50 years old sometimes experiences problems in the intimate sphere which can be called temporary or permanent erectile dysfunction. For men older than 50 years old this figure increases up to every second man.

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